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Aging is a multifactorial phenomenon, a multiscale process that takes place at the molecular (proteins, genes), cellular and tissue levels and represents a complex set of events. This review will focus on the databases related to the aging process and on aging-related biological networks recently constructed to decipher the molecular mechanisms of aging, to characterize the effects of environmental...
Women generally have a reduced risk of cardiovascular disease (CVD). However, this protection of gender diminishes rapidly after menopause and with advancing age, particularly in obese women. Alterations in vascular function are thought to a key early step in the development of atherosclerosis. In this review, we will describe the features of endothelial dysfunction in the post-menopausal obese female...
Although the menopause associates to poor sleep quality, insomnia severity data in the menopausal transition is scarce or lacking.To assess insomnia prevalence, severity and related factors in mid-aged women.In this cross-sectional study 340 women (40 to 59years) completed the Insomnia Severity Index (ISI) and a general questionnaire containing personal/partner data. Hot flush presence and intensity...
Adequate calcium intake is important for optimal bone health. Assessing dietary calcium intake, however, is neither widely done nor standardized in North American clinical practices.Our goal was to validate a calcium assessment tool (CAT), a modified version of the Calcium Calculator™, against the 3-day food record.Data were obtained from 348 participants in the ECKO (Evaluation of the Clinical use...
Data suggest there are established socio-economic disparities associated with mental health although most research has focused on individual-level indicators of socio-economic position. The aim of this study was to investigate the association between mood disorders and area-based socio-economic status (SES), and whether both ends of the SES continuum experienced increased odds for a mood disorder...
Osteoporosis is a common condition associated with aging but has been considered to primarily affect women because of the substantial effect of menopause on osteoporosis. Bone density can decrease with aging in men but occurs more gradually than in postmenopausal women. With improvements in healthcare and extended life expectancy, it is becoming more apparent that osteoporosis affects men and can...
Over 1.5 billion adults worldwide are classified as either overweight or obese, with rates continuing to increase. Obese individuals are at an increased risk for multiple disease processes, particularly type-2 diabetes mellitus (T2DM). Obesity has a strong association with insulin resistance, hyperinsulinemia and glucose intolerance. Adiposity, both subcutaneous and visceral, has been proposed to...
Emerging data reveal that oral estrogen therapy can increase clinic blood pressure (BP) in post-menopausal women; however, it is important to establish its effects on ambulatory BP, which is a better predictor for target-organ damage. Besides estrogen therapy, aerobic training is widely recommended for post-menopausal women, and it can decrease ambulatory BP levels. This study was designed to evaluate...
To compare bone parameters measured by calcaneous quantitative ultrasonography (BUS) in subjects with and without metabolic syndrome (MetS). In addition, we wanted to examine the association of each of the individual components of the syndrome with BUS measurements, to study the relationship between calciotropic hormones or bone turnover markers with BUS parameters in subjects with or without MetS,...
The on-going climate change is predicted to yield a growing number of extreme climate events which will increase in both intensity and frequency. Increased longevity is changing society's demographics. It is very likely this will have a direct impact on population health. Many studies have previously shown that the elderly in a society are among the most vulnerable to heat waves.With a rapidly growing...
To investigate adherence to the urinary function assessments of the national falls guidelines for England and Wales.Secondary data analysis of the 2006 National Clinical Audit of Falls and Bone Health.Acute hospitals in the UK.Patients aged 65years and older with a fragility fracture as a result of a fall.Data were analysed to determine whether patients with fragility fractures received an assessment...
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